Antioxidant proteins are a kind of molecules that can interact with and neutralize free radicals. By donating an electron to rampaging free radicals, antioxidant proteins can terminate the chain reactions caused by free radical intermediates. This protects the cells from further damage or death. The use of antioxidant proteins in pharmacology is intensively studied in recent years. Antioxidant proteins have been investigated for the prevention of diseases such as cancer, coronary heart disease, and even altitude sickness.
AOD (the antioxidant protein database) is a manually curated database of experimentally validated antioxidant proteins. Information including taxonomy, source organism, subcellular location, gene ontology, catalytic activity and function of antioxidant proteins are all extracted from UniProtKB/Swiss-Prot (release 2016_11) and captured in AOD. In addition, links to external databases like SwissProt, NCBI,and Gene Ontology are also provided. As a user-friendly database, a support vector machine based antioxidant protein prediction model, namely AodPred and the sequence analysis tool BLAST are also integrated in the AOD.